Saturday, December 17, 2011

How the major stock indexes fared on Wednesday (AP)

Stocks sank Wednesday as worries about Europe dragged down financial markets. Energy companies fell hard as the price of crude oil plunged 5 percent. Gold fell below $1,600 for the first time in more than two months.

Italy's borrowing rates ratcheted higher and the euro slid below $1.30 for the first time since January, two signs that the debt crisis continues to pressure Europe's governments. The euro has lost more than 3 percent in three days.

The Dow Jones industrial average fell 131.46 points, or 1.1 percent, to close at 11,823.48.

The Standard & Poor's 500 index fell 13.91 points, or 1.1 percent, to 1,211.82.

The Nasdaq fell 39.96, or 1.6 percent to 2,539.31.

For the week:

The Dow is down 360.78 points, or 3 percent.

The S&P is down 43.37, or 3.5 percent.

The Nasdaq is down 107.54, or 4.1 percent.

For the year to date:

The Dow is up 245.97 points, or 2.1 percent.

The S&P is down 45.82, or 3.6 percent.

The Nasdaq is down 113.56, or 4.3 percent.

Source: http://us.rd.yahoo.com/dailynews/rss/energy/*http%3A//news.yahoo.com/s/ap/20111214/ap_on_bi_ge/us_wall_street_box

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Inside Anobit: Why Apple is investing in flash RAM technology ...

Daniel Eran Dilger

Apple?s investments in acquiring flash RAM expertise and technology appear to be centered around packing more storage capacity into Macs and iOS devices at lower prices, with the same level of component reliability and longevity.
This week, Apple was both reported to be close to acquiring flash RAM chip designer Anobit and engaging in plans to set up a semiconductor development center in Isreal, where Anobit is located.

Apple already uses Anobit components in is iOS devices and the MacBook Air. The firm?s unique flash RAM technology, dubbed MSP or ?Memory Signal Processing,? is designed to enhance the reliability, performance, efficiency and endurance of flash RAM.

The pros and cons of flash RAM

Unlike DRAM, which stores memory bits using the state of electrical capacitors which must be continuously refreshed with power, NAND flash RAM stores bits using floating gate transistors, which do not need to be continually bathed in current to maintain their state.

This makes Flash RAM more energy efficient during operation, and allows it to retain its information even after the device is shut down. The use of Flash RAM storage in iOS devices and the MacBook Air provides long term storage of software, documents, music and movies without needing a conventional magnetic hard drive for disk storage.

The use of flash storage not only makes these devices quick to boot up and launch apps, but also slimmer, more battery efficient and less fragile than compatible devices using a conventional hard drive for persistent storage. Particularly on iOS devices, the use of fast flash RAM also limits the need for large amounts of DRAM, further increasing the devices? battery life.

On the flip side however, flash RAM storage is more expensive compared to disk storage, as well as being less reliable and having a shorter life span. The individual cells of flash RAM chips eventually wear out and stop working reliably, requiring specialized software to manage their use.

Strengthening flash RAM

Earlier this year, Apple incorporated TRIM support in Mac OS X Lion. TRIM is an OS level software technology designed to manage the flakey, short lived nature of flash RAM used in Solid State Drives like the MacBook Air?s (pictured below).

Anobit?s MSP technology attacks the same issues, but does so on firmware level, using sophisticated monitoring of flash RAM cells to accurately determine if they are failing or no longer able to reliably store data. These technologies also enable flash RAM to continue to function longer than previously possible by simply working around failures.

In addition to enabling flash RAM to live longer, MSP also promises to make components faster; it enables data to be pushed to flash RAM at speeds that generate more errors, but can then detect and correct the errors.

Cheaper SSDs and flash RAM

A second primary benefit to the MSP technology is that it makes less expensive types of flash RAM usable for a wider range of applications. Most flash RAM used in high speed storage holds one bit per memory cell, known as SLC or ?single level cell? memory.

A cheaper type of flash RAM known as MLC or ?multi level cell? can store two bits per memory cell, making it less expensive to manufacture because it has a higher memory density. A primary problem with MLC is that is more prone to error, requiring more sophisticated management to make it useful.

MSP promises to make cheaper MLC memory components as accurate over the same lifespan as conventional SLC, something that would dramatically change how much storage Apple could pack into its devices and computers at the same price. That would have a huge impact on Apple?s ability to compete, as flash RAM storage is a significant part of the bill of materials in the devices it builds.

NAND flash is the second most expensive component of the iPad (after the touchscreen display), according to iSuppli, accounting for around ten percent of its total component cost. For the MacBook Air, 64GB of SSD flash RAM is similarly estimated to be its second most expensive component (again, after the screen) and roughly the same price as its Intel CPU at a similar 10 percent of the total materials cost.

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Source: http://www.roughlydrafted.com/2011/12/14/inside-anobit-why-apple-is-investing-in-flash-ram-technology/

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Friday, December 16, 2011

Antioxidant has potential in the Alzheimer's fight, UGA researchers find

Wednesday, December 14, 2011

When you cut an apple and leave it out, it turns brown. Squeeze the apple with lemon juice, an antioxidant, and the process slows down.

Simply put, that same "browning" process?known as oxidative stress?happens in the brain as Alzheimer's disease sets in. The underlying cause is believed to be improper processing of a protein associated with the creation of free radicals that cause oxidative stress.

Now, a study by researchers in the University of Georgia College of Pharmacy has shown that an antioxidant can delay the onset of all the indicators of Alzheimer's disease, including cognitive decline. The researchers administered an antioxidant compound called MitoQ to mice genetically engineered to develop Alzheimer's. The results of their study were published in the Nov. 2 issue of the Journal of Neuroscience.

According to the Alzheimer's Society, more than 5 million Americans currently suffer from the neurodegenerative disease. Without successful prevention, almost 14 million Americans will have Alzheimer's by 2050, accounting for healthcare costs of more than $1 trillion a year.

Oxidative stress is believed to cause neurons in the brain to die, resulting in Alzheimer's. Study author James Franklin, an associate professor of pharmaceutical and biomedical sciences, has studied neuronal cell death and oxidative stress at UGA since 2004.

"The brain consumes 20 percent of the oxygen in the body even though it only makes up 5 percent of the volume, so it's particularly susceptible to oxidative stress," said Franklin, coauthor of the study along with Meagan McManus, who received her Ph.D. in neuroscience from UGA in 2010.

The UGA researchers hypothesized that antioxidants administered unsuccessfully by other researchers to treat Alzheimer's were not concentrated enough in the mitochondria of cells. Mitochondria are structures within cells that have many functions, including producing oxidative molecules that damage the brain and cause cell death.

"MitoQ selectively accumulates in the mitochondria," said McManus, who is now studying mitochondrial genetics and dysfunction as a postdoctoral researcher at Children's Hospital of Philadelphia.

"It is more effective for the treatment to go straight to the mitochondria, rather than being present in the cell in general," she said.

Although he had not previously conducted research on Alzheimer's disease, Franklin was moved to approve McManus' research proposal to take his laboratory research in a more clinical direction in part because of her family's history with the disease.

"Two of my grandparents had Alzheimer's disease, but they presented with it very differently. While my granddad often couldn't remember who we were, he was still the same soulful funnyman I'd always loved. But the disease changed my grandmother's mind in a different way, and turned her into someone we'd never known," said McManus.

"So the complexity of the disease was most intriguing to me. I wanted to know how and why it was happening, and more importantly, how to stop it from happening to other people," she said.

In their study, mice engineered to carry three genes associated with familial Alzheimer's were tested for cognitive impairment using the Morris Water Maze, a common test for memory retention. The mice that had received MitoQ in their drinking water performed significantly better than those that didn't. Additionally, the treated mice tested negative for the oxidative stress, amyloid burden, neural death and synaptic loss associated with Alzheimer's.

###

University of Georgia: http://www.uga.edu

Thanks to University of Georgia for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 79 time(s).

Source: http://www.labspaces.net/116000/Antioxidant_has_potential_in_the_Alzheimer_s_fight__UGA_researchers_find

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Video: Risk Management & Retirement

CNBC's Sharon Epperson spoke with financial advisors about how they're positioning their portfolios for "tail risks" in retirement.

Related Links:

Business & financial news headlines from msnbc.com

Source: http://video.msnbc.msn.com/cnbc/45659518/

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Wednesday, December 7, 2011

UK auditors warn Olympic budget is on the edge

LONDON (AP) ? Britain's spending watchdog warned London Olympic organizers Tuesday that they run a risk of exceeding their 9.3 billion-pound ($14.6 billion) budget for hosting the event and have little room for unforeseen costs.

The National Audit Office report concluded that while the venues are on time and largely complete, "not everything is rosy." The report came as British Olympic officials announced that they had doubled the funding for security operations at venues, raising overall security costs for the 2012 Games to more than 1 billion pounds ($1.6 billion).

"The government is confident that there is money available to meet known risks, but, in my view, the likelihood that the games can still be funded within the existing 9.3 billion-pound public sector funding package is so finely balanced that there is a real risk more money will be needed," said Amyas Morse, the head of the National Audit Office.

If that's the case, Olympic officials would be heading back hat in hand to British taxpapers who are already embroiled in tough economic times. The Organization for Economic Cooperation and Development expects the U.K. economy to contract in this current quarter and in the first three months of 2012 and grow only 0.5 percent next year.

Britain's National Audit Office, an independent organization, examines public spending on behalf of Parliament.

Just hours before the report, Olympics minister Hugh Robertson told reporters at a news conference that the London Games remained financially on track ? and within budget contingency planning despite the increased security costs. But the new security costs will certainly become a sensitive political issue.

"We're confident we can do this and remain on budget," Robertson said.

But the auditors noted that only 500 million pounds ($785 million) remains unallocated for dealing with future costs ? a fact that will alarm ministers already trying to stem public anger over cuts in pensions, social services and national programs. Security and transport costs figured among the question marks in the future.

The increase comes after security reviews suggested the initial estimate of 10,000 security guards for the games would not be enough. Thousands of soldiers are now part of the planning, though officials have declined to reveal the exact number.

Robertson made clear that security was not a negotiable item and that the British government was obligated to make sure it took every precaution to make the July 27-Aug. 12 event safe.

The government said an additional 271 million pounds ($424 million) has been allocated to making venues and other sensitive sites, such as hotels, more secure. That means the total cost of securing the venues has climbed to over 553 million pounds ($862 million).

But the rise announced Monday only deals with security guards and other measures needed to protect the venues and related sites. That money is in addition to the cost of paying police and others services to provide overall security for the games. Although Britain's Home Office initially budgeted 600 million pounds ($940 million) for that, that number has been trimmed to 475 million pounds ($745 million).

Authorities say they could only come up with a figure after complex arrangements to actually stage the games were in place. Robertson said an evolving security picture also played a role, suggesting that planners could not have known about the Arab Spring, for example, when first making their plans. He insisted that the British riots last summer, however, did not play a role in the funding increase.

But Tony Travers, a government expert at the London School of Economics, said the riots will serve to spook politicians about planning for "the unknown unknown."

"Security and transport are clearly by a long way the remaining unknown elements in the Olympics being delivered," Travers said. "Security for cost reasons and transport for uncertainty of effectiveness reasons."

The biggest security worry for the Olympics is terrorism. Security has been an intricate part of the games since a terror attack at the 1972 Olympics in Munich killed 11 Israeli athletes and coaches. London has not been immune from terror attacks ? four suicide bombers targeted the city's transit network in 2005, killing 52 commuters.

The British government is planning for the national terror threat to be "severe" during the Olympics, meaning an attempted attack is highly likely. About 12,000 police officers will also be on duty on the busiest days of the games.

Another increase likely to spark discussion was an additional 41 million pounds ($63.9 million) devoted to the Olympic ceremonies. Robertson defended the increase, saying that a proper spectacle was needed to make sure Britain and its tourism industry benefit. Billions of people around the globe are expected to watch the televised opening ceremonies.

"We're just never going to get another moment like this," Robertson said.

Auditors also expressed concern about the failure to finalize transport plans around the venues, pushed back from November to March.

"The experience of spectators, visitors and Londoners in general would be diminished and the reputation of the Games put at risk if these issues were not sorted out," Morse said of the transport and security issues.

Britain's total cost for the event remains at 9.3 billion pounds ($14.6 billion).

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2011-12-05-OLY-London-2012-Security/id-fe90ebee038548bdb31e22cc59497188

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Tuesday, December 6, 2011

Chris Matthews' brother accused of perjury in Pa.

(AP) ? The brother of MSNBC commentator Chris Matthews is accused of lying to a grand jury investigating political corruption in a suburban Philadelphia county.

Montgomery County Commissioner Jim Matthews was arraigned Tuesday on perjury and false-swearing charges stemming from an 18-month grand jury investigation. He was released on $50,000 unsecured bail.

Prosecutors say Matthews lied about his relationship with a title company that does county business.

Matthews is retiring within weeks. His attorney did not immediately return a phone message.

The investigation also concerned breakfast meetings between Matthews, another commissioner and other county officials. Prosecutors say those meetings appeared to be improper but there was not sufficient evidence to establish they were in violation of the state's Sunshine Act.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2011-12-06-Commissioner-Perjury/id-590cabcea39d460493439eaf6a0e6826

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Video: Gingrich gains as Cain suspends campaign



>>> but we begin with nbc news political director and white house correspondent chuck todd . good morning to you.

>> reporter: good morning, matt. by just about every measurement it's safe to say for the moment that newt gingrich has surged to the top with mitt romney . when you dig deep within the polls in new hampshire , a strong argument can be made that it's gingrich and not romney that may deserve to be called front runner . herman cain 's campaign is nearly in the history books.

>> i am suspending my presidential campaign .

>> reporter: but cain 's use of suspension and plan b make it clear he has no plans to leave the gop stage for good. he's even keeping a prior commitment, a rally with oklahoma republicans, tonight. the biggest beneficiary of the cain collapse is newt gingrich . with just four weeks until the first votes are cast, two polls show gingrich 's surge in iowa and new hampshire . in iowa with cain included, gingrich leads the field with 26%, mitt romney and ron paul behind him and herman cain in fourth place with 9%. when you redistribute cain 's vote total among its supporters second choices, gingrich 's lead grows to 28% with paul pulling into a second place tie with romney . in new hampshire mitt romney continues to lead the field with 39%, but gingrich is also surging there with 24%. up nearly 20 points since october. the results are also a red flag for mitt romney , who has seen his support slip significantly in both states since october. he's down seven points in iowa and six points in the state he's made a second home, new hampshire . as for gingrich , in another sign that he and not romney has become the man to beat, opponents and even his former colleagues whom he led as the leader of the 1994 republican revolution are starting to attack.

>> he's as establishment as you get. his address is located on the rodeo drive of washington, which is k street .

>> i think character is definitely an issue. there's all types of leaders. leaders that instill confidence, leaders that are somewhat abrupt and risk, leaders that have one standard for the people that they're leading and a different standard for themselves. i just found his leadership lacking.

>> reporter: today gingrich becomes the latest republican hopeful to meet with businessman donald trump , just after trump announced that he'll moderate a republican debate on december 27th in des moines . so far gingrich is the only candidate to commit. some conservatives aren't happy about trump's involvement.

>> surely it is time for these candidates to do something presidential. stand up and say we're not going to be hijacked.

>> reporter: even the rnc chairman is distancing himself.

>> it's up to the candidates. i mean i don't make those decisions.

>> reporter: and it's unclear whether a donald trump endorsement would actually help. it could hurt in both iowa and new hampshire in our polling, matt, by nearly a two to one margin. in new hampshire voters say they are less likely to support a candidate who gets the support of your next guest.

Source: http://video.today.msnbc.msn.com/today/45550576/

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